Andarine (S4) is a SARM (selective androgen receptor modulator) which has been abandoned during clinical trials. It was developed by the pharmaceutical company GTx, with the hopes it would be used to treat benign prostatic hypertrophy (enlarged prostate), without the nasty sides of drugs like finasteride. Although not the strongest SARM (selective androgen receptor modulator) on paper, it still has good effects on strength, lean muscle, and preventing muscle wasting. Due to this, weightlifters have discovered it the past 5-10 years, and have started utilizing it to help them achieve their fitness goals.
How it works
Andarine (S4) works by binding to androgen receptors, selectively choosing muscle and bone, instead of attacking sex organs like anabolic steroids will. It alters gene expression, causing a boost in protein synthesis and anabolism in the body. By all measured guestimates, Andarine (S4) has about 35% of the binding affinity of straight testosterone. Unlike testosterone, it will not convert to dihydrotestosterone or estrogen. Not only that, but it was developed because it worked at blocking dihydrotestosterone (DHT) from binding to the prostate receptors. (more on this later)
Athletic uses and stacking with SARMs
Andarine (S4) can be used when bulking, cutting, strength recomposition, or just for general wellness. If you use it solo at 50mgs per day you will notice a modest boost in the gym when it comes to strength, lean mass, and fat burning. Here are the best ways to use it for your goals:
Those who want to bulk can stack 50mgs per day of Andarine (S4), with 10mgs a day of RAD140 (Testolone), combined with an increased calorie diet. A typical cycle would be 8-12 weeks.
You can push harder in the gym when it comes to strength by combining 50mgs per day of Andarine (S4) with 10mgs a day Ligandrol (LGD-4033). Users usually report good strength gains after 2-3 weeks.
On paper, you might not assume Andarine (S4) would be great for cutting. But surprisingly, it is very effective especially when stacking 25mgs with 20mgs of Cardarine (GW501516). Users report very good results after 12 weeks on this stack.
Andarine (S4) can be very effective during a recomposition, which means you can lose fat and gain muscle at the same time. Users will stack 50mgs of Andarine (S4), with 25mgs a day of Ostarine Ostabolic (MK2866) + 20mgs a day of Cardarine (GW501516). Combine these three compounds with a caloric deficit and watch the fat melt off without losing muscle. Users will run this cycle for 8-12 weeks.
For those who simply want better mood and greater overall well being, use 25mgs of Andarine (S4) by itself for 8-12 weeks.
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Stacking with steroids
One of the most underrated and underappreciated things that guys miss out on is using Andarine (S4) WITH their anabolic steroids and I will explain why.
Earlier in the article, I mentioned how Andarine (S4) is really good at blocking dihydrotestosterone (DHT) from binding to prostate receptors. A sharp rise in this sex steroid will cause negative side effects like enlarged prostate, increased chance of cancer, and the destruction of head hair follicles. Using Andarine (S4) with your steroids will help offset these side effects, plus it will only add all the benefits of fat loss, lean muscle gains, and strength gains. For this reason, any time you use any sort of testosterone-based steroid I highly recommend stacking in Andarine (S4)!
An example of a stack would be 500mgs a week of Testosterone Cypionate + 25-50mgs a day of Andarine (S4).
- Kevin writes: “I ran Andarine (S4) along with my steroid stack and noticed less of a problem with my prostate and head hair loss. I also saw better endurance, strength, and lean muscle gains than just running my steroids by themselves.”
- Almasy says: “I decided to stack Andarine (S4) and Cardarine (GW501516) as I have been struggling to lose weight even in a calorie deficit. I was able to go from 18% body fat down to 13% body fat in 12 weeks on this stack, and my body weight actually went up 2.5 pounds.”
- Roberto writes. “My bench press went from 300 to 330 thanks to Andarine (S4). I can finally put 3 plates on the bar for the first time in my life!”
Andarine (S4) has one side effect that makes it completely unique to any other SARM (selective androgen receptor modulator) and that is the effect it has on vision. This occurs because it will attach to receptors in the eye.
The result of this is a weird yellow tint you will notice especially at night, or when changing rooms that are lit differently. If you drive at night, you may want to experiment with Andarine (S4) a bit before ramping up your dosage. In my experience, I was able to drive at night no problems, and it actually prevented me from waking up at first sunlight allowing me to sleep longer. This side effect is not in all users and is dose-dependent. For example, I did not notice this issue at 25mgs per day, but I do notice it at 50mgs a day or higher. Once you stop using it, your vision returns to normal within a few days. To learn more about vision side effects read this.
You should not have any sort of estrogenic problems on Andarine (S4). The few reports of water retention or gynecomastia were from those who used product laced with prohormones.
Heart strain or aggression should not occur either. Once again, those that report this issue were likely using products laced with something else, perhaps clenbuterol or a prohormone.
Andarine (S4) is slightly suppressive and you will need to run a mini-PCT (post cycle therapy) when you conclude its usage. I recommend a simple 4-8 weeks of Hcgenerate ES at 5 capsules per day.
Half-life and detection
Andarine (S4) half-life is only 4-6 hours. This means some users may want to dose it twice a day. This short half life can be advantageous in those who want to get rid of their vision side effects, since it will be out of your system much faster than other compounds.
It is unclear the exact detectable time but it is estimated to be 2-4 weeks. It is banned in all major athletic leagues, so be careful if you are a tested athlete, as it is considered cheating.
Where can I buy Andarine
Andarine (S4) is like other SARMs (selective androgen receptor modulators), which are sold under a gray part of the law. Banned by almost all payment processors in the United States, finding it domestically has become challenging. The good news is sarms1.com still sells it, but that may not last very much longer as Congress wants it banned.